Connection system having a threaded nut

ABSTRACT

The present invention relates to a connection system for components through which fluid flows in medicine and medical equipment, comprising a male connection cone (6, 30) and a threaded nut (7) least partially surrounding the connection cone (6) and having an internal thread (9), for captively connecting the male connection cone (6, 30) to a female receptacle of an additional component through which fluid flows. The invention is characterised in that the threaded nut (7) has radially circumferential through-holes (10) at least in some sections in the axial section of the circumferential jacket of the threaded nut and webs (11, 11′) are formed adjacent to the through-holes in the circumferential jacket, sections of the internal thread (9) being arranged on the inside of said webs in relation to the circumferential jacket. Furthermore, the invention also relates to the production of the connection system and to its use.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a national phase filing under 35 USC § 371 ofinternational application No. PCT/EP2013/076428 filed 12 Dec. 2013,which claims priority to German Application No. 10 2012 112 212.1 filed13 Dec. 2012. The entire contents of each of the above-mentionedapplications are incorporated herein by reference.

FIELD OF THE INVENTION

The present invention relates to a connection system for fluidconnections as used, in particular, in medicine and medical equipment.

BACKGROUND OF THE INVENTION

Connection systems for fluid connections are known in the state of artand are, for example, used in the fields of medicine and medicalequipment. The connection systems are used in the fields of infusion,artificial nutrition, with syringes and injection equipment, intransfusion and in the supply or transfer of various flow media, and asinjection equipment in the context of medical and pharmaceuticaldevices, which inter alia also comprise several components.

In medicine, among other things absolute safety in the handling ofsyringes, infusion tubes, cannulae etc. is of the utmost importance. Forthis reason, in medical technology, the Luer principle or Luer lockprinciple has prevailed vis-à-vis previously common connection systems.Luer lock is a standardised connection system for cannulae, syringes andinfusion tubes in the medical field.

In this design, a seal is achieved by a conical construction of theconnection components (the so-called Luer cone). The internal cone ofone connection side is also referred to as “female”, and the externalcone of the opposite side is referred to as “male”. The cone has astandard gradient of 6%.

If, for the purpose of securing or locking the connection againstinadvertent disconnection, the cone is supplemented by a threaded nut orunion nut with a thread, the system is referred to as a Luer lock. Thesimpler version without a screw thread on the syringe nozzle is referredto as a Luer connector, Luer adapter or Luer slip.

The Luer lock system ensures compatibility among various manufacturersand is internationally recongised. Worldwide, the Luer lock connectionhas established itself for reversible connections of syringes, cannulae,infusion tubes, spinal needles and the like. This represents a greatadvantage, in particular in the context of international aid anddisaster operations.

At the same time, however, the universality of the system is associatedwith a dramatic disadvantage and with resulting dangers. Because of itsuniversal standardisation the Luer lock connection has inherentpossibilities for mix-ups because the system is compatible for vascularapplications (veins and arteries) and for spinal or periduralapplications(spiral cord), partly also for enteral applications (e.g.feeding tubes) and respiratory applications (airways). Thus thisconnection technique basically does not prevent, for example, medicationthat has to be injected venously from erroneously being applied spinally(into the spinal fluid). Unfortunately, several cases of such mix-upswith fatal consequences have occurred.

Apart from the above, from the point of view of process technology themanufacture of the threaded nut or the union nuts, as they are used,inter alia, in the Luer lock system, is relatively expensive, becausefor the internal thread of the nut during the manufacture in plasticinjection moulding, a tool that can be rotated out or folded out needsto be used. This results in a significant increase in tool costs andincreased manufacturing expenditure. The disadvantage is particularlysignificant if a plural number of such threads are provided on onecomponent.

BRIEF SUMMARY OF THE INVENTION

It is the object of the present invention to at least partly overcomethe disadvantages known from the state of the art. This relates on theone hand to an increase in user safety, and on the other hand tosimplification of the manufacturing process.

The object of the present invention is met by a connection system asdisclosed herein. Preferred embodiments of the invention form part ofthe subordinate claims, in particular also the method for manufacturingthese connection systems and their use in the fields of medicine andmedical equipment.

The connection system according to the invention for components throughwhich fluid flows in medicine and medical equipment comprises at leastone male connection cone and a threaded nut at least partiallysurrounding this connection cone and having an internal thread (nutthread).

In this design the threaded nut is in particular used for captivelyconnecting the male connection cone to a female receptacle of anadditional component through which fluid flows. In particular the femalereceptacle comprises external projections that engage the internalthread of the threaded nut. By rotation of the male connection cone intothe female receptacle the components are connected in a fluid-tight andcaptive manner.

According to the present invention in some sections the threaded nut hasradially circumferential through-holes in the axial section of itscircumferential jacket, as a result of which through-holes webs or websections are formed in the circumferential jacket. According to thepresent invention, furthermore, the threaded nut comprises the sectionsof the internal thread on the inside of the above-described webs.

In this document the term “sections of the internal thread” refers, inparticular, to the thread flanks of the corresponding screw threadswhich are arranged adjacent to the through-holes, i.e. on the inside ofthe webs or web segments. According to the present invention the flanksof the internal thread essentially extend parallel to the through-holesand are also limited to these regions or sections. This cancorrespondingly be provided on all the webs or web elements, or only onsome of these webs or web sections.

According to the present invention the term “web” refers to a structuralfeature of the circumferential jacket which at least on one side isadjacent to the circumferential through-hole. Furthermore, these webscan also be adjacent to two through-holes, wherein this is notmandatory.

For a better understanding of the present invention it should bementioned that inter alia the through-holes are due to the manufacturingprocess in which parts of the tool project through the outer jacket ofthe threaded nut, thus providing the mould for binding the internalthread on the inside of the threaded nut or union nut in the injectionmoulding process.

The internal thread, manufactured in this manner, of a threaded nut thusprovides an advantage in that no tool or tool section arranged withinthe thread needs to be provided for its manufacture. By simple linearclosing and opening of the injection moulding tool, including the slidegate that may be necessary, thus a mould for an internal thread isprovided, by means of which thread the internal screw threads of thethreaded nut can be produced. This type of manufacture is associatedwith an advantage in that no rotatable or fold-out tool components needto be used to form the internal thread, and thus the cycle times in theinjection moulding process can be reduced. Furthermore, a reduction inweight and material savings in the manufacture of the product areachieved.

According to a further particularly preferred embodiment of the presentinvention, the internal thread of the threaded nut is a double thread ora triple thread. It should also be taken into account that according toa further particularly preferred embodiment for each screw thread atleast two through-holes are provided that are, for example, arrangedopposite each other at the circumference of the threaded nut.

If triple threads are used, the through-holes are arranged so as to beoffset by 120 degrees from each other, wherein for each alignment andthread entrance at least one or two, in particular three, through-holesare provided that in the axial direction are arranged one above theother, with in each case a corresponding section of the internal threadbeing arranged on their inside.

According to a further particularly preferred embodiment of the presentinvention, the through-holes, which in sections are radiallycircumferential and which preferably on the inside adjoin sections ofthe internal thread, extend over a third, in particular over at leasttwo thirds, of the circumference, wherein the calculation relates to asum of the corresponding internal thread structures for each pitchheight, i.e. for each 360 degrees. In this context it is alsoadvantageous that either by way of the number of screw threads or thenumber of revolutions of the screw thread the desired strength orstability of the screw connection can be influenced. Thus an increase inthe number of screw threads is not only associated with an increase inthe “gripability” of the thread but also with an increase in thestability and strength of the connection with otherwise identicaldesign. In this context the term “gripability” refers to the type ofthread design that makes it easier for a user to connect the externalthread of the female counterpart with the threaded nut. The“gripability” increases as the number of threads increases, because thepossible number of receiving locations for the counterpart in thethreaded nut increases.

Preferably, the corresponding internal thread sections, which areprovided in the case of double, and in particular in the case of triple,threads, are arranged axially one behind the other corresponding to thepitch height of the screw thread used.

According to a further particularly preferred embodiment of the presentinvention, apart from the webs, which extend in the circumferentialjacket, reinforcement braces are provided by means of which, inparticular, the webs are supported in the region of the through-holes.It should be taken into account that the webs, which preferably on theinside comprise a thread section, can be of a relatively thin design andthat in particular with the use of double-thread connection systemsrelatively large forces act on the thread section. In order to ensurethat these forces can be safely absorbed, and in order to at leastpartly prevent breaking of the webs and thus of the thread sections,according to this particular embodiment the reinforcement braces arearranged in the region between the attachment points to thecircumferential jacket. Consequently, in particular the forces actingwhen a counterpart is screwed in can better be absorbed and dissipatedwithout the component breaking.

For example, the median distance to the circumferential jacket thatadjoins in the radial direction can be a possible attachment point forthe reinforcement braces, wherein the reinforcement braces extendpreferably so as to be axially parallel to the connection cone arrangedin the interior of the threaded nut. As an alternative to this, theconnection braces can also be arranged at an acute obtuse angle to thewebs, wherein this angle is preferably between 75° and 90°.

According to a further particularly preferred embodiment of the presentinvention the present connection system does not have the dimensions ofthe standardised Luer system but as a result of modification of thecorresponding dimensions provides protection against any mix-up. Thisensures that as a result of different design sizes, the presentconnection system is incompatible with the Luer system that is, forexample, commonly used in medical applications. This ensures, inparticular, that with the use of the present connection system, forexample in the field of artificial nutrition, any mix-up with connectionsystems as used, for example, in the field of infusion or injectionequipment, can be excluded. To this effect the external diameter of theinternal thread comprises, in particular, a diameter that is greaterthan 7.83 mm and preferably greater than 7.83 mm and smaller than 20 mm.According to a further particularly preferred embodiment the externaldiameter of the internal thread is greater than 8 mm and smaller than 10mm and is, in particular, approximately 9 mm.

Apart from the external diameter, according to a further particularlypreferred embodiment, the pitch height of the internal thread can bemodified from the dimension used in the Luer system; according to thepresent invention said pitch height is preferably greater than 1.3 mm,furthermore greater than 1.3 mm and smaller than 5 mm. According to afurther particularly preferred embodiment the pitch height is, inparticular, greater than 1.5 mm and smaller than 3 mm and particularlypreferably between 1.8 mm and 2.5 mm.

According to a further particularly preferred embodiment of the presentinvention at least some parts of the connection system are made from amaterial selected from a group comprising duroplastics andthermoplastics and in particular polyphenylene sulfide, polypropylene,poly-1-butene, polyvinyl chloride, polyvinylidene chloride, polymethylmetaacrylate, polymethyl methacrylate, polyacrylonitrile, polystyrene,polysulfone, polyacetal, polyvinyl alcohol, polyvinyl acetate, ethylenevinyl acetate (EVA), mixtures comprising ethylene vinyl acetate andpolyethylene, ethylene vinylacetate copolymer (EVAC) for example Elvaxor Evatane, ionomers, fluorocarbon plastic, polyethylene, polyamide inparticular a partially aromatic polyamide, polycarbonate, polyester,polyphenylene oxide, polysulfone, polyvinyl acetal, polyurethane, andchlorinated polyether, cellulose nitrate, cellulose acetate, celluloseether, phenolic resin, urea resin, thiourea resin, melamine resin, alkylresin, allyl resin, silicon, polyimide, polybenzimidazole, epoxy resin,casein plastic, crosslinked polyurethane, unsaturated polyester resin,antimicrobial or antiseptic material such as for example highly-poroussilver, silver manufactured without ions, silver alloys and inparticular microsilver, metal-ions-releasing compounds, materials freeof bisphenol A for example Tritan, Terlux,acrylonitrile-butadiene-styrene, combinations thereof and the like.

According to a further particularly preferred embodiment of the presentinvention the threaded nut is non-rotatably connected to the connectioncone, and in particular formed in one piece with the connection cone.

According to an alternative embodiment to the above the connection conecomprises a radially circumferential groove in which the nut thread isdesigned as a union nut and is rotatably arranged. To this effect theconnection cone and this union nut are manufactured in separate processsteps and are subsequently mechanically interconnected.

The object of the present invention is also met by an injection mouldingmethod for the manufacture of a connection system as described above,wherein this method only comprises the manufacture of a connection conewith a non-rotatably connected threaded nut or union nut, as a singlecomponent.

To this effect the method comprises the closing of the mould to form atleast the connection cone and/or the threaded nut or union nut, thesubsequent retraction of a slide gate to form flow paths and spaceswithin the component, the injection of the plastic material, the coolingof the plastic material in the mould, the extension of the slide gates,and the opening of the mould for removing (demoulding) the plasticcomponents.

With this method it becomes clear that contrary to the otherwisenormally-used slide gates to form the flow paths, in other words inparticular rotatable slide gates, nonrotational slide gates can be usedto form the internal threads of the threaded nut or union nut becausethe formation of the internal threads is provided by way of the externalshape of the tools. This provides the particularly preferred advantagein that additional rotary movements within the tool, in particular theslide gates, can be so that the mould can be implemented economically,in particular in the production of a multitude of corresponding internalthreads in different positions of a connection system, for example withthe use of multiway valves. In this design the economical manufactureresults from shortening the cycle times in the injection mouldingprocess. For example, the typical cycle time in the manufacture of unionnuts is approximately 21 to 22 seconds in the injection mouldingprocess, wherein before and after injection the corresponding threadslide gates need to be rotated in or out. In comparison to this, in themanufacture of the threaded nut or union nut according to the inventionthe cycle time can be reduced by approximately 4 to 5 seconds. Moreover,as a result of the simplified design of the mould the correspondingassociated costs are reduced by up to 40%. For example, in the case ofsimple tools there is no need to provide additional equipment such ascore pull devices.

Apart from the connection system and its method for manufacture, thepresent invention also relates to the use of the connection system forthe manufacture of corresponding components through which fluid flows inmedicine and medical equipment, for example infusion tubes ortransfusion tubes, Y-connectors, multiway valves, multiple distributors,injection equipment such as syringes, access devices or similar, as wellas combinations thereof.

Below, the invention is explained with reference to various exemplaryembodiments in the use of the connection system in combination withthree-way valves, wherein it is expressly stated that the invention isnot limited to these exemplary embodiments. Instead, the scope of thepresent invention requires a broad interpretation of the connectionsystem in terms of its use according to the invention, and that, inparticular, modifications as they would be made by the average personskilled in the art for the purpose of adaptation to correspondingcomponents are also within the scope of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS

The following are shown:

FIGS. 1a to 1c a three-way valve with a connection system according tothe invention;

FIGS. 2a and 2b the three-way valve of FIG. 1 but without the plug;

FIGS. 3a and 3b an alternative embodiment, in which the union nut isrotatably arranged in a further manufacturing step;

FIGS. 4a to 4d diagrammatic illustrations of the plastic injectionmoulding tools for manufacturing a three-way valve with a connectioncone with and without a threaded nut; and

FIGS. 5a to 5e an alternative embodiment of the threaded nut withreinforcement webs.

DETAILED DESCRIPTION OF THE PRESENTLY PREFERRED EMBODIMENTS

FIG. 1 shows a first embodiment of the connection system according tothe invention in combination with a three-way valve 1. Apart from thehousing 2 the plug 3 and the connection points 4 a, 4 b and 5 are shown.On the connection 5 the connection cone 6 with the threaded nut 7 isshown, wherein FIG. 1a in a lateral view apart from the circumferentialjacket also shows the internal thread 9. According to the embodimentshown in the diagram, said internal thread 9 extends in each case byapproximately 135 degrees so that on the right-hand side and on theleft-hand side of the circumferential jacket spaces 19 result. The topview 1 c clearly shows the through-holes 10 that determine the web 11 orthe web section 11′. In FIG. 1b the three-way valve 1 with theconnection system according to the invention is shown in a furtherlateral view, wherein here again in particular the through-holes 10 andthe web section 11′ are shown. In the embodiment shown, the threaded nut7 is firmly connected to the connection cone 6 or to the connectionpoint 5. To establish a connection with a female receptacle, theaforesaid is screwed into the nut 7 so that the male connection cone isreceived and is connected in a fluid-proof manner to the femalereceptacle (not shown).

FIGS. 2a and 2b show a perspective view of the housing 2 with thethreaded nut 7 according to the invention, wherein for the sake ofclarity the plug is not shown. These illustrations again, apart from theconnections 4 a and 4 b, show the connection 5 on which the threaded nut7 is arranged. As already shown in FIG. 1c , said threaded nut 7comprises the through-holes 10 and the web 11 or web section 11′. Thecomponent of FIG. 2b corresponds to the component of FIG. 2a , whereinin this illustration, in addition, the connection cone 6 is clearlyshown. Furthermore, internally, the screw threads 12 and 13 are shownthat extend on the inside adjacent to the through-holes 10.

FIGS. 3a and 3b show an alternative embodiment of the arrangement of theconnection system according to the invention, wherein in this embodimenta union nut (not shown) can be clipped onto the connection cone 30,which union nut then correspondingly snaps into the circumferentialgroove 31. As a result of this joining of the two components a rotatableunion nut is created which in particular provides an advantage in thatthe three-way valve, for example in the application for connecting themale connection cone 30 to a female receptacle (not shown), need not berotated. The diagram shows particularly clearly that the connection cone30 apart from the conical gradation 32 at the front end comprises afurther conical thickening 33 that is used, in particular, in connectionwith the female receptacle, to provide a corresponding seal of theconnection system. In this design preferably an embodiment of a unionnut is selected as shown with reference to FIGS. 1 and 2, however,without the corresponding three-way valve but with a central aperture atthe rear for receiving the connection point 30 and for clicking into thecircumferential groove 31.

FIGS. 4a to 4d show the two mould components 40 and 40′ (4 a and 4 c:internal view; 4 b and 4 d: external view) for the manufacture of theconnection system according to the invention in combination with athree-way valve, wherein apart from the recesses for the fluidconnections 51 and 52 on the right-hand side the connection 53 is alsoshown, at which in conjunction with the connection cone by means of theprojections 55 the jacket of the threaded nut is perforated and on theinside corresponding screw threads are produced. To this effect, duringmanufacture, a corresponding slide gate moves into the space of theconnection 53, with the aforesaid forming the internal counterpart tothe external mould. Analogously the same also applies to the fluidconnections 51 and 52, which do not comprise a union nut or an internalscrew thread. FIGS. 4c and 4d show the counterpart to the tool of FIGS.4a and 4b , wherein apart from the corresponding component elements theinjection points 45 and 56 are also shown. FIG. 4d shows the injectionpoints on the rear of the tool.

According to the established method for the manufacture of suchinjection moulding components, in the injection moulding process the twocomponents 4 a/4 b and 4 c/4 d are joined, thus forming the base body ofthe three-way valve with the threaded nut or union nut according to theinvention. As a result of the insertion of corresponding slide gates(not shown) into the apertures 51, 52, 53 or 41, 42, 43 the spaces forthe fluid paths are created. With this injection mould, furthermore,apart from producing the nut with the internal thread as describedabove, it is also possible to produce the three-way valve with a fixedthreaded nut on the right-hand side and a three-way valve with acircumferential groove 44 for receiving or arranging a union nut on theleft-hand side. Thus the embodiment shown in the diagram forms bothalternatives of a connection system with a fixed threaded nut and arotatable union nut, wherein the latter needs to be produced andarranged in at least one further manufacturing step.

FIGS. 5a to 5e show a further embodiment of the present invention. Thus,FIG. 5a shows a lateral view from the right-hand side, FIG. 5b a frontview, FIG. 5c a lateral view from the left-hand side, and FIG. 5d a topview. FIG. 5c shows a partial section view of the connection points 4 aand 4 b and the region of the threaded nut with the connection point 5.In this embodiment the radially circumferential webs 11 or 11′ have beensupplemented by means of reinforcement braces 60. These reinforcementbraces, which in the present example are arranged so as to be parallelto the main direction of extension of the connection point 5, are used,among other things, to prevent any breaking of the thread when a femaleconnector is screwed in. Thus, the female connectors or connectionpieces are usually provided with circumferential segments or with twosegments on the thread. Above all in the case of a double thread, theload on the thread section of the threaded nut is increased, and timeand again breakage of the thread has been observed. The reinforcementbraces shown in this exemplary embodiment can prevent such breaking, andtherefore also provide the option of using female connectors/connectiondevices comprising various plastics (for example duroplastics andthermoplastics and in particular polyphenylene sulfide, polypropylene,poly-1-butene, polyvinyl chloride, polyvinylidene chloride, polymethylmetaacrylate, polymethyl methacrylate, polyacrylonitrile, polystyrene,polysulfone, polyacetal, polyvinyl alcohol, polyvinyl acetate, ethylenevinyl acetate (EVA), mixtures comprising ethylene vinyl acetate andpolyethylene, ethylene vinylacetate copolymer (EVAC) for example Elvaxor Evatane, ionomers, fluorocarbon plastic, polyethylene, polyamide inparticular a partially aromatic polyamide, polycarbonate, polyester,polyphenylene oxide, polysulfone, polyvinyl acetal, polyurethane, andchlorinated polyether, cellulose nitrate, cellulose acetate, celluloseether, phenolic resin, urea resin, thiourea resin, melamine resin, alkylresin, allyl resin, silicon, polyimide, polybenzimidazole, epoxy resin,casein plastic, crosslinked polyurethane, unsaturated polyester resin,antimicrobial or antiseptic material such as for example highly-poroussilver, silver manufactured without ions, silver alloys and inparticular microsilver, metal-ions-releasing compounds, materials freeof bisphenol A for example Tritan, Terlux,acrylonitrile-butadiene-styrene, combinations thereof and the like).Furthermore, in FIGS. 5a to 5e components that essentially correspond tothe exemplary embodiments of the above-mentioned designs have the samereference characters.

LIST OF REFERENCE CHARACTERS

-   1 Three-way valve-   2 Housing-   3 Plug-   4 a, 4 b, 5 Connection points-   6, 30 Male connection cone-   7 Threaded nut-   9 Internal thread-   10 Through-holes-   11, 11′ Webs-   12, 13 Screw threads-   19 Space-   30 Connection cone-   31 Groove-   32 Conical gradation-   33 Thickening-   40, 40′ Mould components-   41, 42, 43 Apertures-   44 Circumferential groove-   45 Injection gate-   51, 52, 53 Fluid connections/apertures-   53 Connection-   55 Projections-   56 Injection gate-   60 Reinforcement brace

The invention claimed is:
 1. A connection system for components throughwhich fluid flows in medicine and medical equipment, the connectionsystem comprising: a male connection cone; and a threaded nut includinga circumferential jacket having an axial section at least partiallysurrounding the connection cone and having an internal thread, thethreaded nut captively connecting the male connection cone to a femalereceptacle of an additional component through which fluid flows, thethreaded nut having through-holes radially spaced about a circumferenceof the circumferential jacket in at least some portions of the axialsection of the circumferential jacket, wherein webs are formed in thecircumferential jacket adjacent to the through-holes, wherein sectionsof the internal thread are arranged on an inner surface of said webs inopposing relation to the through-holes and the internal thread sectionsare capable of being formed by projections of a mould through thethrough-holes opposing the internal thread sections, wherein thethrough-holes are at least as large as the opposing internal threadsections, wherein the internal thread sections are at least flanks ofthe internal thread, and wherein the internal thread sections arelimited to regions of the webs; wherein reinforcement braces are alsoformed in the circumferential jacket adjacent to the through-holes andthe reinforcement braces are arranged at an angle to the webs; andwherein an edge of each of two of said through-holes is defined alongone side of one of the reinforcement braces, with an edge of each ofanother two of said through-holes defined along another side of said oneof the reinforcement braces.
 2. The connection system according to claim1, wherein the internal thread is a double thread or a triple thread. 3.The connection system according to claim 2, wherein for each thread ofthe double thread or the triple thread at least two through-holes areprovided.
 4. The connection system according to claim 1, wherein theradially spaced through-holes and/or sections of the internal threadextend over at least ⅓ of the circumference of the circumferentialjacket.
 5. The connection system according to claim 1, wherein at leastone of (i) a maximum diameter of the internal thread is greater than7.83 mm and smaller than 20 mm, and (ii) a pitch of the internal threadis greater than 1.3 mm and smaller than 5 mm.
 6. The connection systemaccording to claim 1, wherein at least some parts of the connectionsystem are made from a material selected from a group consisting ofduroplastics and thermoplastics and polyphenylene sulfide,polypropylene, poly-1-butene, polyvinyl chloride, polyvinylidenechloride, polymethyl metaacrylate, polymethyl methacrylate,polyacrylonitrile, polystyrene, polysulfone, polyacetal, polyvinylalcohol, polyvinyl acetate, ethylene vinyl acetate (EVA), mixturescomprising ethylene vinyl acetate and polyethylene, ethylenevinylacetate copolymer (EVAC) ionomers, fluorocarbon plastic,polyethylene, polyamide, a partially aromatic polyamide, polycarbonate,polyester, polyphenylene oxide, polysulfone, polyvinyl acetal,polyurethane, and chlorinated polyether, cellulose nitrate, celluloseacetate, cellulose ether, phenolic resin, urea resin, thiourea resin,melamine resin, alkyl resin, allyl resin, silicon, polyimide,polybenzimidazole, epoxy resin, casein plastic, crosslinkedpolyurethane, unsaturated polyester resin, antimicrobial or antisepticmaterial, highly-porous silver, silver manufactured without ions, silveralloys and microsilver, metal-ions-releasing compounds, materials freeof bisphenol A, Tritan, Terlux, acrylonitrile-butadiene-styrene, andcombinations thereof.
 7. The connection system according to claim 1,wherein the threaded nut is designed as a Luer lock component and isrotatably connected to the connection cone.
 8. The connection systemaccording to claim 1, wherein the connection system is capable of beingused with infusion tubes, transfusion tubes, Y-connectors, multiwayvalves, multiple distributors, injection equipment, syringes, accessdevices, and combinations thereof.
 9. An injection moulding method forthe manufacture of a connection system, the method comprising: selectinga mould configured to make a threaded nut including a circumferentialjacket having an axial section configured to at least partially surrounda male connection cone and having an internal thread, the threaded nutconfigured to captively connect the male connection cone to a femalereceptacle of an additional component through which fluid flows, thethreaded nut having through-holes radially spaced about a circumferenceof the circumferential jacket in at least some portions of the axialsection of the circumferential jacket, wherein webs are formed in thecircumferential jacket adjacent to the through-holes, wherein sectionsof the internal thread are arranged on an inner surface of said webs inopposing relation to the through-holes and are formed by projections ofthe mould through the through-holes opposing the internal threadsections, wherein the through-holes are at least as large as theopposing internal thread sections, wherein the internal thread sectionsof the internal thread are at least the flanks of the internal thread,wherein the internal thread sections are limited to regions of the webs;wherein reinforcement braces are also formed in the circumferentialjacket adjacent to the through-holes and the reinforcement braces arearranged at an angle to the webs; and wherein an edge of each of two ofsaid through-holes is defined along one side of one of the reinforcementbraces, with an edge of each of another two of said through-holesdefined along another side of said one of the reinforcement braces;closing the mould; injecting a plastic material; cooling the plasticmaterial in the mould; and opening the mould and demoulding the threadednut having the internal thread sections formed by the projections of themould through the through-holes opposing the internal thread sections.10. A connection system for components through which fluid flows inmedicine and medical equipment, the connection system comprising: a maleconnection cone; and a threaded nut including a circumferential jackethaving an axial section at least partially surrounding the connectioncone and having an internal thread, the threaded nut captivelyconnecting the male connection cone to a female receptacle of anadditional component through which fluid flows, the threaded nut havingthrough-holes radially spaced about a circumference of thecircumferential jacket in at least some portions of the axial section ofthe circumferential jacket, wherein webs are formed in thecircumferential jacket adjacent to the through-holes, wherein sectionsof the internal thread are arranged on an inner surface of said webs inopposing relation to the through-holes and the internal thread sectionsare capable of being formed by projections of a mould through thethrough-holes opposing the internal thread sections, wherein thethrough-holes are at least as large as the opposing internal threadsections, wherein the internal thread sections are at least flanks ofthe internal thread, and wherein the internal thread sections arelimited to regions of the webs; wherein reinforcement braces are alsoformed in the circumferential jacket adjacent to the through-holes andthe reinforcement braces are arranged at an angle to the webs; andwherein two of said reinforcement braces, opposed to each other, extendaxially along the circumferential jacket and an edge of each of two ofsaid through-holes is defined along one side of each of the tworeinforcement braces, with an edge of each of another two of saidthrough-holes defined along another side of the respective reinforcementbrace.